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Target intelligence / Profile preview
Abelson Murine Leukemia Viral Oncogene Homolog Protein Tyrosine Kinase (Abl)
- Target
- Abl
- Molecular classification
- Enzyme, Protein Kinase, Tyrosine Kinase
01
Overview
Abl is a non-receptor protein tyrosine kinase encoded by the *ABL1* gene in humans. It is ubiquitously expressed and found in both the cytoplasm and nucleus of cells. The protein plays critical roles in regulating cell differentiation, division, adhesion, stress response (including DNA repair), and cytoskeletal remodeling. Its activity is tightly regulated by autoinhibitory domains and post-translational modifications. Dysregulation of Abl, particularly through the BCR-Abl fusion in CML, makes it a key therapeutic target.
- Other names
- Tyrosine-protein kinase ABL1c-AblProto-oncogene tyrosine-protein kinase ABL1JTK7p150[7]
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Cell differentiationCell divisionCell adhesionStress responseDNA repairCytoskeletal remodelingActin cytoskeleton regulationDNA damage responseCell cycle controlNeuronal development
04
Disease associations
Chronic Myelogenous LeukemiaBreast CancerMature B-cell LymphomaIschemiaCancerInfection
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