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Target intelligence / Profile preview
Abelson Non-Receptor Tyrosine Kinase (ABL)
- Target
- ABL
- Molecular classification
- Non-receptor tyrosine kinase, Enzyme
01
Overview
Abelson non-receptor tyrosine kinases are a family of cytoplasmic and nuclear protein tyrosine kinases, primarily represented by ABL1 (also known as c-Abl) and ABL2 (also known as Arg). These enzymes play crucial roles in regulating diverse cellular processes, including cell division, differentiation, adhesion, migration, stress response (such as DNA repair), and apoptosis. Constitutive activation due to genetic alterations is implicated in several cancers, notably chronic myeloid leukemia. Small molecule inhibitors targeting Abl kinase activity such as imatinib have become paradigms for targeted cancer therapy.
- Other names
- ABL1c-AblABL2ArgBCR-ABL fusion protein (if applicable)
02
Mechanism of action
Inhibition of Abl kinase activity
03
Biological functions
Cytoskeletal regulationCell growth/survivalDNA repairCell divisionDifferentiationAdhesionMigrationStress responseApoptosisReceptor endocytosisAutophagy
04
Disease associations
CancerChronic Myeloid Leukemia
05
Safety considerations
Resistance to inhibitorsOff-target effects
06
Interacting drugs
07
Biomarkers
BCR-ABL fusion gene
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