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Target intelligence / Profile preview
Tyrosine-protein kinase ABL1 (ABL1)
- Target
- ABL1
- Molecular classification
- Non-receptor tyrosine kinase, Enzyme
01
Overview
Tyrosine-protein kinase ABL1 is a multifunctional non-receptor tyrosine kinase essential for regulating diverse cellular processes related to proliferation, differentiation, migration/adhesion, survival/apoptosis—and when dysregulated through mutation or fusion events—acts as an oncogenic driver most notably implicated in chronic myeloid leukemia but also involved across several cancers and infectious disease mechanisms.
- Other names
- c-AblAbelson tyrosine-protein kinase 1proto-oncogene c-Abl
02
Mechanism of action
Inhibition of BCR–ABL kinase activity
03
Biological functions
Cell growth and division (proliferation)Maturation (differentiation)Movement (migration)SurvivalProgrammed cell death (apoptosis)Cytoskeleton remodelingCell cycle regulationDNA repairStress response signalingRegulation of gene expressionAntigen receptor signalingSynapse formation
04
Disease associations
Chronic Myeloid Leukemia (CML)Breast cancerIschemia-related conditionsMature B-cell lymphomaInfection
05
Safety considerations
Oncogenic potentialMitochondrial dysfunction and apoptosis
06
Interacting drugs
07
Biomarkers
BCR-ABL1 fusion protein
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