Abhydrolase domain-containing protein 12B (ABHD12B)

Abhydrolase domain-containing protein 12B (ABHD12B) is a protein coding gene in humans belonging to the alpha/beta hydrolase domain-containing family, similar to its paralog ABHD12[3]. It is predicted to function as a lysophospholipase and monoacylglycerol lipase, participating in lipid metabolic processes such as the catabolism of monoacylglycerol and phosphatidylserine[3]. The protein localizes to the endoplasmic reticulum membrane. Mutations or alterations in ABHD12B have been associated with rare conditions such as aggressive periodontitis and Chanarin-Dorfman syndrome, but its precise physiological and pathological roles are still being elucidated[3]. The protein is structurally related to ABHD12, which is known to be a major lysophosphatidylserine lipase in the brain and is implicated in neurological processes, but there are no published data that directly implicate ABHD12B in these central nervous system functions or in the same set of diseases as ABHD12, such as PHARC[1][3].

Other names

ABHD12BC14orf29BEM46L3Abhydrolase domain-containing 12BAlpha/beta hydrolase domain-containing protein 12Bprotein ABHD12Bc14_5314

Not established; based on gene family, likely involves inhibition of lysophospholipase or monoacylglycerol lipase activity[3].