Abhydrolase domain-containing protein 14A (ABHD14A)

Abhydrolase domain-containing protein 14A (ABHD14A) is a human protein comprising 271 amino acids that features a conserved alpha/beta hydrolase fold, characteristic of the serine hydrolase superfamily. It is a predicted enzyme with hydrolase activity and is thought to localize to the membrane and cytoplasm. While ABHD14A is implicated, by sequence similarity and domain structure, in metabolic processes and possibly granule neuron development, its precise biochemical function in humans has not yet been experimentally validated. Some reports associate it genetically with rare diseases such as Chanarin-Dorfman syndrome and Williams-Beuren syndrome, but direct mechanistic links are lacking. Given its sequence similarity to ABHD14B—which functions as a lysine deacetylase—some databases conflate the two, highlighting a need for more specific annotation and study. ABHD14A is broadly expressed in many tissues but is not currently an established therapeutic target, nor is it linked to any approved drugs, mechanisms of drug action, biomarkers, or specific clinical safety concerns.

Other names

Protein ABHD14AABHD14AUNQ1913/PRO4373DKFZP564O243DORZ1Alpha/beta hydrolase domain-containing protein 14Aabhydrolase domain-containing protein 14A

No mechanisms of action are known for drugs against this molecule, due to absence of pharmacological agents or chemical probes targeting ABHD14A.