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Target intelligence / Profile preview
ABI family member 3 (ABI3)
- Target
- ABI3
- Molecular classification
- Adaptor protein, Intracellular signaling molecule, Component of the Abi/WAVE complex
01
Overview
ABI family member 3 (ABI3) is a protein-coding gene encoding an adaptor protein characterized by a homeobox homology domain, a proline-rich region, and a Src-homology 3 (SH3) domain. It is a critical component of the Abi/WAVE complex, which regulates actin polymerization and subsequently influences cell motility and migration. ABI3 is notable for its putative role as a tumor metastasis inhibitor, reducing both cell migration and metastatic potential in vitro, potentially through interactions with p21-activated kinase. Multiple transcript variants exist due to alternative splicing. While associated with certain cancer types and innate immune responses, ABI3 is not a receptor, enzyme, or well-characterized therapeutic target in drug discovery.
- Other names
- NESHNew molecule expressed in spleen and hematopoietic cellsABI gene family member 3ABI3_HUMAN
02
Mechanism of action
Not applicable, as no drugs reported to directly target ABI3 as of current knowledge
03
Biological functions
Regulation of actin cytoskeleton and actin polymerizationInhibition of tumor cell metastasisInhibition of cell migrationInvolvement in cell signal transduction, including regulation of postsynapse organizationPositive regulation of cellular senescenceDefense response to tumor cell
04
Disease associations
Cancer (inhibitor of metastasis and cell motility; associated with diffuse large B-cell lymphoma, activated B-cell type)Immunodeficiency 72
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