ABI family member 3 binding protein (ABI3BP)

ABI family member 3 binding protein (ABI3BP) is an extracellular matrix-associated protein with poorly defined but emerging roles in health and disease. Initially identified as a binding partner for the SH3 domain of ABI3, ABI3BP is widely expressed in multiple organs, including the heart, vasculature, lungs, and various cancer tissues[1][3]. It promotes cellular senescence, stabilizes cell-substrate interactions, and regulates cell-extracellular matrix adhesion, particularly important in cardiovascular tissues and during tissue remodeling. In the heart, altered expression of ABI3BP is observed with heart failure and cardiomyopathy, suggesting involvement in pathological extracellular matrix remodeling and cardiac progenitor cell differentiation[1]. In oncology, ABI3BP generally functions as a tumor suppressor, with downregulation found in numerous cancers and its expression associated with improved prognosis and immune microenvironment modulation[3]. Though not considered a conventional drug target such as a receptor or enzyme, ABI3BP may serve as a prognostic biomarker and has been linked to drug sensitivity (notably to cyclin-dependent kinase inhibitors such as AT7519) in cancer contexts[3]. At this time, its physiological and molecular actions continue to be actively investigated[1][3].

Other names

Target of Nesh-SH3Nesh-binding proteinTARSHNESHBPDKFZP586L2024ABI gene family member 3-binding proteinNeshBPtarget of Nesh-SH3ABI gene family, member 3 (NESH) binding proteinABI3BP

Not a direct therapeutic target; sensitivity to cell-cycle inhibition via cyclin-dependent kinase targeting (e.g., AT7519)