ABL1 and Src family tyrosine kinases (ABL1 and Src family)

The ABL1 tyrosine kinase is a non-receptor enzyme, encoded by the ABL1 gene on chromosome 9, involved in cell signaling pathways regulating proliferation, differentiation, survival, apoptosis, migration, and cytoskeletal dynamics through actin modulation. In its mutant or fusion form (BCR-ABL1), it drives chronic myeloid leukemia and other cancers by constitutive activation. The kinase possesses multiple functional domains (KD, SH2, SH3), with tightly regulated activity and complex structural dynamics. The Src family tyrosine kinases are related enzymes, each with unique cellular roles but sharing mechanisms of signal transduction and oncogenesis, implicated in various cancer types and also targeted by kinase inhibitor drugs.\n\nNote: The target "ABL1 and Src family tyrosine kinases" collectively refers to multiple individual proteins rather than a single molecule, and information should be parsed for either ABL1 or each Src family member for specific experimental or clinical use.

Other names

Abelson murine leukemia viral oncogene homolog 1Abelson tyrosine-protein kinase 1c-Ablproto-oncogene c-AblJTK7p150Proto-oncogene tyrosine-protein kinase SrcFynYesLynLckHckBlkFgrYrkSrc kinases

TKIs (Tyrosine kinase inhibitors) bind to kinase domain, blocking ATP-binding and kinase activity, thereby inhibiting downstream signaling critical for cell proliferation and survival. Allosteric inhibitors (e.g., asciminib for ABL1) bind outside the ATP site, further modulating kinase activity.