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Target intelligence / Profile preview
ABL1 Tyrosine-Protein Kinase (ABL1)
- Target
- ABL1
- Molecular classification
- Enzyme, Tyrosine Kinase, Non-receptor tyrosine kinase, Proto-oncogene
01
Overview
ABL1 is a non-receptor tyrosine kinase that plays a crucial role in various cellular processes, including cell proliferation, differentiation, adhesion, and stress response. It is involved in DNA repair and apoptosis, particularly in response to DNA damage and oxidative stress. The ABL1 gene is a proto-oncogene, and mutations or translocations involving this gene, such as the BCR-ABL1 fusion, can lead to cancer.
- Other names
- c-ABLAbelson tyrosine-protein kinase 1
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Cell ProliferationCell DifferentiationCell AdhesionDNA RepairApoptosisStress responseRegulation of actin cytoskeleton
04
Disease associations
CancerChronic Myeloid Leukemia (CML)Acute Lymphoblastic Leukemia (ALL)Infection
05
Safety considerations
Resistance to tyrosine kinase inhibitorsOff-target effects of TKIs
06
Interacting drugs
07
Biomarkers
BCR-ABL1 fusion gene
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