Abnormal tissue destruction via thermal injury

Abnormal tissue destruction via thermal injury" refers to the damage caused to tissues following exposure to excessive temperatures, leading to denaturation of proteins, cell membrane disruption, interruption of cellular homeostasis, thrombosis of local vasculature, and various forms of cell death including necrosis and apoptosis[2][3][5]. This process is not a discrete molecular target, receptor, or protein, but rather a description of a clinical and pathological phenomenon that can affect various tissues in the body, most frequently the skin in the case of burns. The mechanisms involved include protein denaturation, membrane disruption, mitochondrial dysfunction, oxidative stress, calcium influx, and activation of regulated cell death pathways[2][3][4]. "Abnormal tissue destruction via thermal injury" should not be considered a molecular target such as a receptor, enzyme, or transporter. There is no single molecule with this name; therefore, this is not a suitable entry for a molecular target database.

Other names

Thermal injuryBurn injuryHeat-induced tissue destruction