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Target intelligence / Profile preview
Abnormal Vaginal Lactobacilli
- Molecular classification
- Bacteria, Microbiome component
01
Overview
Abnormal vaginal lactobacilli refers to deviations in the quantity, species composition, or function of Lactobacillus bacteria within the vaginal microbiome. These abnormalities can manifest as either a deficiency (depletion) or an overgrowth of lactobacilli, each associated with distinct clinical syndromes and implications for vaginal health. These abnormalities are not direct drug targets but rather conditions arising from imbalances in the vaginal microbiome, which are addressed with therapies like antibiotics or alkalinizing agents.
- Other names
- Vaginal dysbiosisLactobacillus deficiencyLactobacillus overgrowthBacterial vaginosis (BV)Aerobic vaginitisCytolytic vaginosis (CV)Vaginal lactobacillosis
02
Mechanism of action
Antibiotic targeting of anaerobic/aerobic pathogens; Alkalinization to counteract excess lactic acid.
03
Biological functions
Maintenance of vaginal pHProduction of lactic acidProduction of antimicrobial compoundsInhibition of pathogen colonizationEpithelial cell lysis (in overgrowth)
04
Disease associations
Bacterial vaginosisAerobic vaginitisCytolytic vaginosisVaginal lactobacillosisVaginitisIncreased risk for infectionInflammationAdverse pregnancy outcomes
05
Safety considerations
Antibiotic resistanceDisruption of normal vaginal floraMisdiagnosis of cytolytic vaginosis as candidiasisOveruse of antifungals
06
Interacting drugs
Clindamycin
3 more in the full profile.
07
Biomarkers
Nugent scoreVaginal pHMicroscopic examination of vaginal discharge (presence of clue cells, lactobacilli, epithelial cell lysis)
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