Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Absent in Melanoma 2 (AIM2)
- Target
- AIM2
- Molecular classification
- ALR family, PYHIN family, Cytosolic DNA sensor, Inflammasome component
01
Overview
AIM2 is a cytosolic sensor protein that detects double-stranded DNA (dsDNA) and initiates inflammatory responses. It forms the AIM2 inflammasome, activating caspase-1 and processing pro-inflammatory cytokines IL-1β and IL-18. AIM2 also regulates regulatory T cell stability and can act as a tumor suppressor by inhibiting the PI3K/AKT/mTOR signaling pathway.
- Other names
- Interferon-inducible protein AIM2PYHIN4
02
Mechanism of action
AIM2 binds to cytosolic dsDNA, leading to inflammasome formation, caspase-1 activation, and subsequent maturation of IL-1β and IL-18. In cancer, AIM2 inhibits PI3K/AKT/mTOR signaling.
03
Biological functions
Innate immunityInflammasome formationCaspase-1 activationIL-1β and IL-18 maturationPyroptosisT regulatory cell stabilityTumor suppression
04
Disease associations
Infectious disease defenseAutoimmunityAutoinflammationCancer (tumor suppression)Systemic lupus erythematosusSjögren’s syndromePsoriasisSystemic sclerosis
05
Safety considerations
Aberrant activation in autoimmune diseases due to inappropriate sensing of self-DNA
Beyond the preview
Go deeper on Absent in Melanoma 2 (AIM2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Absent in Melanoma 2 (AIM2).