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Target intelligence / Profile preview
AC005392.3 (novel transcript, antisense to CD177)
- Molecular classification
- Other (Natural antisense transcript)
01
Overview
AC005392.3 is a non-coding RNA, described as a "novel transcript, antisense to CD177," which is transcribed from the DNA strand opposite the CD177 gene on chromosome 19. Natural antisense transcripts can regulate sense transcript dynamics by affecting transcription initiation, transcript processing, stability, and chromatin architecture, thereby influencing gene expression[2][5][8]. However, there is no direct evidence that this specific antisense transcript (ENSG00000272396) is involved in disease or considered a direct therapeutic target. Its biological role, if any, would likely be mediated through modulation of CD177 gene expression, but there is no current evidence for drug targeting or biomarker utility[1][4][5][8].
- Other names
- AC005392.3novel transcript, antisense to CD177
02
Biological functions
Gene expression regulation (via antisense mechanisms)Antisense transcripts can modulate the transcription, stability, and processing of the corresponding sense transcript (CD177 in this context)
03
Disease associations
OtherNo direct implication in disease is documented for this specific antisense transcript; however, antisense RNAs can broadly affect gene expression, potentially contributing to disease processes if they modulate functionally relevant targets
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