Target intelligence / Profile preview

Acceptance and Commitment Therapy (ACT)

Target
ACT
01

Overview

Acceptance and Commitment Therapy (ACT) is a form of psychotherapy and a clinical behavioral intervention based on Relational Frame Theory (RFT) (NIH, 2023). Unlike traditional cognitive-behavioral therapy, ACT does not focus on changing the content of problematic thoughts but rather on changing the individual's relationship with them (Association for Contextual Behavioral Science, 2024). The primary goal is to foster psychological flexibility, which allows individuals to stay in the present moment and persist in or change behavior based on their chosen values (Kashdan & Rottenberg, 2010). ACT is clinically indicated for a wide range of mental health conditions, including depression and anxiety, as well as managing the psychological impact of chronic physical illnesses like chronic pain (StatPearls, 2023). Because ACT is a psychological methodology rather than a biological molecule, it does not possess a molecular classification, a biochemical mechanism of action, or a pharmacological target profile (PubMed, 2024). It is frequently used as an adjunct to pharmacotherapy but does not interact with drugs at a molecular level (Wikipedia, 2024).

Other names
Contextual Cognitive Behavioral TherapyThird-Wave Behavior TherapyACT Therapy
02

Mechanism of action

Promotion of psychological flexibility through six core processes: acceptance, cognitive defusion, being present, self-as-context, values, and committed action (Hayes et al., 2006).

03

Biological functions

Psychological flexibilityCognitive defusionMindfulnessValues-based behavioral regulation
04

Disease associations

DepressionAnxiety disordersChronic painPost-traumatic stress disorder (PTSD)Substance use disorderObsessive-compulsive disorder (OCD)
05

Safety considerations

Temporary emotional distress during therapeutic processingPatient non-adherencePotential misinterpretation of acceptance as resignation or passivity
06

Biomarkers

Acceptance and Action Questionnaire (AAQ-II)Five Facet Mindfulness Questionnaire (FFMQ)Mindful Attention Awareness Scale (MAAS)

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