Target intelligence / Profile preview

Accessory obturator nerve (AON)

Target
AON
Molecular classification
Other (Peripheral nerve; anatomical variant of lumbar plexus)
01

Overview

The accessory obturator nerve is a relatively rare anatomical variant present in approximately 10–30% of individuals. It typically arises from the lumbar plexus, most often from the ventral rami of the L3 and L4 spinal nerves, and descends along the medial border of the psoas major muscle, crossing the superior pubic ramus beneath the pectineus muscle. Its primary role is to provide motor innervation to the pectineus muscle (sometimes to other adductor muscles), and sensory innervation to the hip joint and, variably, to the skin over the medial thigh. The presence and course of the accessory obturator nerve are highly variable, which can affect clinical outcomes during regional nerve blocks or pelvic/hip surgeries. It is not considered a druggable therapeutic target, receptor, enzyme, or related molecular entity; rather, it is a named anatomical structure of clinical importance during nerve blocks and surgical interventions.

Other names
Accessory obturator
02

Biological functions

Motor innervation (hip adductor muscles, especially pectineus)Sensory innervation (hip joint, sometimes medial thigh)
03

Disease associations

Other (variation impacts surgical approaches and neural injury; not a classic therapeutic target)
04

Safety considerations

Anatomical variation may lead to inadvertent injury during pelvic/hip surgeriesMay be missed in obturator nerve blocks, affecting anesthesia efficacy

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