Acellular human dermal matrix (ADM)

Acellular human dermal matrix (ADM) is a decellularized, non-immunogenic scaffold derived from human cadaveric skin, primarily composed of extracellular matrix (ECM) components such as collagen, elastin, and glycosaminoglycans [1, 2]. It is processed to remove all cellular and antigenic materials while preserving the structural and biochemical integrity of the dermal layer [4, 5]. ADM serves as a biological framework that facilitates host cell infiltration, revascularization, and tissue regeneration in various clinical applications, including breast reconstruction, chronic wound management, and hernia repair [2, 10]. By mimicking the native tissue environment, it promotes organized remodeling and reduces the risk of scarring and foreign body response [11, 13]. Although not a molecular drug target in the traditional sense, ADM is a critical therapeutic biomaterial used to support and replace damaged soft tissues [1, 7].

Other names

Human acellular dermal matrixHADMDecellularized dermal matrixAllogenic acellular dermal matrixBiologic scaffoldBiologic matrixDermal allograft

Acts as a three-dimensional scaffold that mimics the native extracellular matrix (ECM), providing structural support and biochemical cues (such as collagen and elastin) that facilitate host cell infiltration, revascularization, and tissue remodeling, eventually being replaced by host tissue.