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Target intelligence / Profile preview
Acetaminophen Metabolism (APAP Metabolism)
- Target
- APAP Metabolism
- Molecular classification
- Metabolic Pathway
01
Overview
Acetaminophen metabolism involves three principal pathways: glucuronidation, sulfation, and cytochrome P450 oxidation. The cytochrome P450 pathway produces NAPQI, a toxic metabolite detoxified by glutathione. In overdose, glutathione depletion leads to NAPQI accumulation and hepatotoxicity.
- Other names
- Paracetamol Metabolism
02
Mechanism of action
N/A
03
Biological functions
Drug metabolismDetoxificationXenobiotic metabolism
04
Disease associations
HepatotoxicityAcute liver failure
05
Safety considerations
Hepatotoxicity (overdose)Drug interactions altering metabolismGlutathione depletionRisk increased by alcohol use or pre-existing liver disease
06
Interacting drugs
Acetaminophen
4 more in the full profile.
07
Biomarkers
Acetaminophen plasma concentrationNAPQI levels (research)Glutathione levelsLiver function tests (ALT, AST)
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