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Target intelligence / Profile preview
Acetaminophen-Protein Adducts (APAP-Protein Adducts)
- Target
- APAP-Protein Adducts
- Molecular classification
- Protein Adducts
01
Overview
Acetaminophen toxicity arises from the formation of the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI). When glutathione (GSH) stores are depleted, NAPQI covalently binds to hepatic proteins, particularly mitochondrial proteins, resulting in protein dysfunction, oxidative stress, cell death, and liver injury. The resulting acetaminophen-protein adducts are clinically relevant biomarkers for APAP-induced liver injury.
- Other names
- NAPQI-Protein AdductsAcetaminophen toxic metabolite bindingAPAP-Protein BindingNAPQI protein adducts
02
Mechanism of action
N/A - This is a consequence of acetaminophen metabolism and protein binding, not a direct drug target.
03
Biological functions
Cell death inductionProtein dysfunctionOxidative stress inductionImmune response activation
04
Disease associations
Acetaminophen-induced liver injuryDrug-induced hepatotoxicityAcute liver failure
05
Safety considerations
Acetaminophen overdoseHepatotoxicityAcute liver failure
06
Interacting drugs
Acetaminophen
1 more in the full profile.
07
Biomarkers
APAP-protein adducts
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