Acetoacetyl-CoA synthetase pseudogene 1 (AACSP1)

Acetoacetyl-CoA synthetase pseudogene 1 (AACSP1) is annotated as a pseudogene, related by sequence to the functional enzyme acetoacetyl-CoA synthetase (AACS), which catalyzes the conversion of acetoacetate to acetoacetyl-CoA, a key reaction in lipid and cholesterol biosynthesis[4]. Unlike AACS, AACSP1 is not described as encoding an active protein and is not implicated in any characterized biological processes or diseases. There is no evidence AACSP1 acts as a therapeutic target (enzyme, receptor, transporter, etc.), nor is it involved in drug interactions or patient selection. As a pseudogene, it may be transcribed, but there are no data supporting a relevant molecular or clinical role, and the ambiguity or absence of information means this is not a correct or actionable target. If information is required for acetoacetyl-CoA synthetase, use the canonical gene/protein (AACS) instead[4]. If AACSP1 is referenced as a drug target, this is likely incorrect—data should focus on the functional enzyme acetoacetyl-CoA synthetase (AACS), which is relevant to lipid metabolism and ketone body utilization[4]. No sources suggest AACSP1 is a functional entity; thus, it should be classified as "incorrect" for drug targeting or target annotation.

Other names

AACSP1AACS pseudogene 1