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Acetyl-CoA Carboxylase 2 (ACC2)
- Target
- ACC2
- Molecular classification
- Enzyme, Carboxytransferase, Biotin-dependent enzyme
01
Overview
Acetyl-CoA Carboxylase 2 (ACC2) is a biotin-dependent enzyme localized to the outer mitochondrial membrane. It catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA, a key regulatory step in fatty acid metabolism. ACC2 regulates fatty acid oxidation by producing malonyl-CoA, which inhibits carnitine palmitoyltransferase 1 (CPT1), controlling the entry of long-chain fatty acids into mitochondria for β-oxidation. It is predominantly expressed in heart and skeletal muscle, making it a therapeutic target for obesity, metabolic diseases, and cardiac hypertrophy.
- Other names
- ACACBACCβacetyl-Coenzyme A carboxylase betaacetyl-CoA carboxylase beta
02
Mechanism of action
Inhibition of ACC2 to increase fatty acid oxidation by decreasing malonyl-CoA levels, leading to increased CPT1 activity.
03
Biological functions
Fatty acid β-oxidation regulationRegulation of lipid metabolismRegulation of energy production
04
Disease associations
ObesityMetabolic diseaseCardiac hypertrophy
05
Safety considerations
Knockout studies in mice did not show significant effects on body weight, suggesting potential limitations in therapeutic efficacy.Potential for off-target effects due to structural similarity with ACC1.
06
Interacting drugs
ACC2 inhibitors
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