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Acetyl coenzyme A synthetase (None)
- Target
- None
- Molecular classification
- Enzyme, Ligase
01
Overview
Acetyl coenzyme A synthetase (ACS) is an enzyme (EC 6.2.1.1) that catalyzes the activation of acetate by converting it into acetyl-CoA. This reaction is crucial for cellular metabolism, linking energy production in the tricarboxylic acid (TCA) cycle, fatty acid synthesis, and other biosynthetic pathways. There are multiple isoforms, including ACSS1 (mitochondrial) and ACSS2 (cytoplasmic/nuclear). ACS plays a role in energy metabolism, biosynthesis, and epigenetic regulation. Dysregulation or mutation can impact energy homeostasis, and targeted manipulation has implications in cancer biology.
- Other names
- Acetate-CoA ligaseAcs
02
Mechanism of action
Inhibition of acetyl-CoA production
03
Biological functions
Energy metabolismFatty acid synthesisCholesterol synthesisEpigenetic regulationMetabolic flexibilityAcetyl-CoA production
04
Disease associations
CancerMetabolic disorders
05
Safety considerations
Dysregulation can impact energy homeostasisPotential off-target effects due to broad metabolic role
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