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Target intelligence / Profile preview
Acetylcholine-Dependent Potassium Channel (I_K,ACh)
- Target
- I_K,ACh
- Molecular classification
- Ion Channel, Potassium Channel, Inwardly Rectifying Potassium Channel (Kir), Ligand-Gated Ion Channel
01
Overview
The acetylcholine-dependent potassium channel is an essential component linking parasympathetic neurotransmission with electrical regulation of cardiac rhythm. Its unique mechanism—direct activation via Gβγ subunits following M2 receptor engagement—and its critical role in controlling heart rate make it both physiologically vital and clinically significant as a therapeutic target for arrhythmias such as atrial fibrillation.
- Other names
- Muscarinic Potassium ChannelKAChGIRK channel (when referring to the specific channel subunits)M2 Receptor-Activated K+ Channel
02
Mechanism of action
G-protein βγ subunit-mediated activation leads to potassium efflux and cellular hyperpolarization.
03
Biological functions
Cardiac Action Potential ModulationHeart Rate RegulationCell HyperpolarizationRegulation of Neuronal Excitability
04
Disease associations
Atrial FibrillationCardiac ArrhythmiasBradycardiaSick Sinus Syndrome (in some cases)
05
Safety considerations
BradycardiaHypotensionDrug interactions with muscarinic agonists/antagonistsPotential for pro-arrhythmic effects in certain contexts
06
Interacting drugs
Acetylcholine
3 more in the full profile.
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