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Target intelligence / Profile preview
Acetylcholine Receptor Alpha1 Subunit (CHRNA1)
- Target
- CHRNA1
- Molecular classification
- Receptor, Ligand-gated ion channel
01
Overview
The acetylcholine receptor alpha1 subunit, encoded by the CHRNA1 gene, is a critical component of the nicotinic acetylcholine receptor (nAChR) found primarily at neuromuscular junctions. This subunit plays a central role in binding acetylcholine and initiating channel gating, which leads to muscle contraction. It is a major antigenic target in autoimmune myasthenia gravis and mutations are associated with congenital myasthenic syndromes.
- Other names
- ACHRACHNRA
02
Mechanism of action
Agonist binding opens cation channel, leading to muscle cell depolarization and contraction.
03
Biological functions
Neuromuscular communicationSynaptic transmissionSignal transduction
04
Disease associations
Myasthenia gravisCongenital myasthenic syndromes
05
Safety considerations
Autoimmune response (myasthenia gravis)Mutations leading to congenital myasthenic syndromes
06
Interacting drugs
Acetylcholine
1 more in the full profile.
07
Biomarkers
Antibodies against CHRNA1 (in myasthenia gravis)
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