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Target intelligence / Profile preview
Acetylcholine Receptor Delta Subunit (CHRND)
- Target
- CHRND
- Molecular classification
- Ligand-gated ion channels, Acetylcholine receptors
01
Overview
The acetylcholine receptor delta subunit is a protein component of the muscle-type nicotinic acetylcholine receptor (AChR), encoded by the CHRND gene in humans. This receptor is a ligand-gated ion channel that mediates synaptic transmission at neuromuscular junctions. Upon binding acetylcholine, all subunits undergo conformational changes leading to opening of the central pore for cation flow.
- Other names
- ACHRD
02
Mechanism of action
Agonist-induced opening of ion channel, leading to muscle cell depolarization.
03
Biological functions
Synaptic transmissionIon channel activityMuscle contraction
04
Disease associations
Multiple pterygium syndrome, lethal type (LMPS/MUPSL)Congenital myasthenic syndromes involving AChRsArthrogryposis multiplex congenita
05
Safety considerations
Mutations can lead to severe congenital myasthenic syndromes and arthrogryposis.
06
Interacting drugs
Acetylcholine
1 more in the full profile.
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