Acetylcholine Receptor Gamma Subunit (None)

The acetylcholine receptor gamma subunit (AChR γ-subunit) is a protein component of the nicotinic acetylcholine receptor (nAChR), specifically found in skeletal muscle. Encoded by the CHRNG gene, this subunit is part of a ligand-gated ion channel mediating synaptic transmission at neuromuscular junctions, enabling communication between nerve and muscle cells essential for movement. The γ-subunit is present in fetal muscle and is later replaced by the ε-subunit in adult muscle. It plays a critical role in the formation of AChR clusters during development. Mutations in CHRNG can cause congenital myasthenic syndromes.

Other names

AChR gamma subunitCHRNGNicotinic acetylcholine receptor gamma subunitAcetylcholine receptor protein gamma subunit

Agonist binding leading to ion channel opening and subsequent muscle cell depolarization.