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Target intelligence / Profile preview
Acetylcholine receptor subunit beta 1 (CHRNB1)
- Target
- CHRNB1
- Molecular classification
- Ligand-gated ion channel, Cys-loop superfamily, Receptor
01
Overview
The acetylcholine receptor beta1 subunit is a component of the muscle-type nicotinic acetylcholine receptor (nAChR), a ligand-gated ion channel that mediates synaptic transmission at neuromuscular junctions. It is essential for muscle contraction and mutations are associated with congenital myasthenic syndromes.
- Other names
- Acetylcholine receptor beta1 subunitAChR beta1Cholinergic receptor nicotinic beta 1 subunit
02
Mechanism of action
Agonist or antagonist binding to the acetylcholine receptor, modulating ion channel activity
03
Biological functions
Acetylcholine bindingIon channel activityRegulation of membrane potentialSynaptic transmissionNeuromuscular junction transmission
04
Disease associations
Slow-channel congenital myasthenic syndrome
05
Safety considerations
Potential for neuromuscular blockadeAutoimmune reactions targeting the receptor
06
Interacting drugs
Acetylcholine
2 more in the full profile.
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