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Target intelligence / Profile preview
Acetylcholine Release in Ileal Smooth Muscle (ACh Release (Ileal Smooth Muscle))
- Target
- ACh Release (Ileal Smooth Muscle)
- Molecular classification
- Neurotransmission, Smooth Muscle Physiology
01
Overview
Acetylcholine (ACh) release in ileal smooth muscle is a crucial process for regulating gastrointestinal motility. ACh, released from cholinergic neurons in the enteric nervous system, acts on muscarinic acetylcholine receptors (mAChRs), predominantly the M3 subtype, to stimulate smooth muscle contraction. This process is modulated by factors like nitric oxide (NO), which inhibits ACh release. Pharmacological agents like muscarinic antagonists (e.g., atropine) and cholinesterase inhibitors (e.g., eserine) can modulate this system, influencing intestinal motility.
- Other names
- Acetylcholine Signaling in Ileal Smooth MuscleCholinergic Neurotransmission in IleumIleal Smooth Muscle Contraction via Acetylcholine
02
Mechanism of action
Modulation of acetylcholine release, muscarinic receptor antagonism, cholinesterase inhibition.
03
Biological functions
Gastrointestinal MotilityMuscle ContractionNeurotransmission
04
Disease associations
Gastrointestinal DisordersMotility DisordersIrritable Bowel Syndrome (IBS)ConstipationDiarrhea
05
Safety considerations
Anticholinergic Side Effects (e.g., dry mouth, constipation)Drug InteractionsOverstimulation of Cholinergic System (e.g., with cholinesterase inhibitors)
06
Interacting drugs
Atropine
4 more in the full profile.
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