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Target intelligence / Profile preview
Acetylcholine-sensitive potassium channel (IKACh)
- Target
- IKACh
- Molecular classification
- Ion channel, Potassium channel, Inwardly rectifying potassium channel, G protein-gated ion channel
01
Overview
The acetylcholine-sensitive potassium channel (IKACh) is a G-protein-gated inwardly rectifying potassium channel predominantly found in cardiac tissue. It is formed by Kir3.1 and Kir3.4 subunits and activated by acetylcholine via M2 receptors, leading to heart rate reduction. IKACh plays a critical role in regulating heart rate and rhythm, and its dysfunction is associated with increased risk of arrhythmias.
- Other names
- Muscarinic-gated K+ channelG-protein-gated inward rectifier K+ channel
02
Mechanism of action
Activated by G protein βγ subunits following M2 muscarinic receptor stimulation, leading to potassium efflux and cell hyperpolarization.
03
Biological functions
Regulation of heart rateModulation of pacemaker activityRegulation of membrane potentialParasympathetic signaling
04
Disease associations
ArrhythmiaAtrial fibrillationCardiac rhythm instability
05
Safety considerations
Loss-of-function mutations can lead to arrhythmiasAltered signaling dynamics can increase arrhythmia susceptibility
06
Interacting drugs
Acetylcholine
2 more in the full profile.
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