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Target intelligence / Profile preview
Acetylcholinesterase (AChE)
- Target
- AChE
- Molecular classification
- Enzyme, Serine hydrolase, Cholinesterase
01
Overview
Acetylcholinesterase (AChE) is a serine hydrolase enzyme that catalyzes the rapid hydrolysis of the neurotransmitter acetylcholine (ACh) into choline and acetic acid. It is primarily found at neuromuscular junctions and cholinergic brain synapses and plays a crucial role in terminating synaptic transmission by removing ACh from the synaptic cleft. Inhibition of AChE leads to the accumulation of acetylcholine, causing prolonged stimulation, and is the basis for toxicity seen with organophosphorus compounds. Therapeutic inhibitors are used in the treatment of Alzheimer’s disease and certain neuromuscular disorders.
02
Mechanism of action
Hydrolyzes acetylcholine into choline and acetic acid, terminating synaptic transmission.
03
Biological functions
Neurotransmitter degradationSynaptic transmission terminationRegulation of cholinergic neurotransmission
04
Disease associations
Alzheimer's diseaseNeuromuscular disordersOrganophosphorus poisoning
05
Safety considerations
Excessive cholinergic stimulationToxicity due to irreversible inhibitionDrug interactions
06
Interacting drugs
Donepezil
3 more in the full profile.
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