Acetylserotonin O-methyltransferase-like protein (ASMTL)

Acetylserotonin O-methyltransferase-like protein (ASMTL) is a bifunctional enzyme encoded by the ASMTL gene, located in the pseudoautosomal region of the X and Y chromosomes in humans. It possesses two distinct functional domains: an N-terminal domain homologous to bacterial Maf proteins and a C-terminal domain similar to N-acetylserotonin O-methyltransferase (ASMT). ASMTL hydrolyzes dTTP and UTP (and to a lesser extent other nucleotides), suggesting a role in nucleotide metabolism and potentially in preventing the incorporation of modified nucleotides into nucleic acids. Although its C-terminal domain implies possible methyltransferase activity, direct enzymatic activity for N-acetylserotonin methylation by ASMTL is not well established in contrast to its paralog ASMT. ASMTL is expressed in various tissues, where it may regulate cell division and nucleotide pool balance. Its precise physiological function and disease associations are still under investigation[2][3][5].

Other names

ASMTLAcetylserotonin O-methyltransferase likeAcetylserotonin O-methyltransferase-like proteinN-acetylserotonin O-methyltransferase-like proteinASMTLXASMTLYASTMLProbable bifunctional dTTP/UTP pyrophosphatase/methyltransferase proteindTTP/UTP pyrophosphataseNucleotide PPaseNucleoside triphosphate pyrophosphataseNucleotide pyrophosphatase