Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Achaete-scute family bHLH transcription factor 2 (ASCL2)
- Target
- ASCL2
- Molecular classification
- Transcription Factor, bHLH family
01
Overview
Achaete-scute family bHLH transcription factor 2 (ASCL2) is a basic helix-loop-helix (bHLH) transcription factor. Under normal physiological conditions, ASCL2 is primarily expressed in intestinal stem cells and placenta. In cancer, ASCL2 becomes aberrantly overexpressed and has been identified as a tumor-associated antigen in several malignancies. It plays a critical role in maintaining stemness phenotype, promoting tumor growth and progression, and contributing to immune evasion. Targeting ASCL2 may sensitize tumors to immunotherapies.
02
Mechanism of action
Inhibition of ASCL2 can arrest tumor growth and sensitize tumors to immunotherapies.
03
Biological functions
Stemness maintenanceEpithelial-mesenchymal transition (EMT) promotionImmune exclusionRegulation of WNT/β-catenin signalingRegulation of Hippo/YAP-KLF5 signalingTGFB-mediated CAF activation
04
Disease associations
Cancer
05
Biomarkers
ASCL2 expression level
Beyond the preview
Go deeper on Achaete-scute family bHLH transcription factor 2 (ASCL2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Achaete-scute family bHLH transcription factor 2 (ASCL2).