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Acid–base balance via provision of metabolizable anions
- Molecular classification
- Metabolite, Electrolyte
01
Overview
The strategy of administering metabolizable anions (lactate, acetate, or gluconate) in intravenous fluids to correct or maintain acid–base homeostasis. These anions are metabolized into bicarbonate (HCO₃⁻), which buffers excess hydrogen ions (H⁺) and regulates blood pH.
- Other names
- Metabolizable Anions (Lactate/Acetate/Gluconate)Lactate administration for acid-base balanceAcetate administration for acid-base balanceGluconate administration for acid-base balanceAlkalinizing IV fluids
02
Mechanism of action
Cellular metabolism of lactate, acetate, or gluconate leading to the generation of bicarbonate (HCO₃⁻), which buffers excess hydrogen ions (H⁺) and increases blood pH.
03
Biological functions
Acid-base homeostasisBufferingElectrolyte balance
04
Disease associations
Metabolic acidosisHyperchloremic metabolic acidosisFluid resuscitation
05
Safety considerations
Metabolic alkalosis (overcorrection)Vasodilation (with high acetate doses)Reduced myocardial contractility (with high acetate doses)Electrolyte imbalances (sodium, potassium, calcium)Fluid overload
06
Interacting drugs
Ringer's Lactate
4 more in the full profile.
07
Biomarkers
Blood pHPlasma bicarbonate concentrationLactate levelsAcetate levelsGluconate levelsBase excess
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