Acid-base buffer anion

The term **"Acid-base balance via buffer anions"** does not refer to a single molecule or receptor but rather describes the physiological process by which various **buffer systems**—primarily involving weak acids and their conjugate bases—maintain the body's pH within a narrow range. The most important buffers in human physiology are the **bicarbonate-carbonic acid system**, the **phosphate system**, and protein buffers such as hemoglobin[1][2][3][4]. These systems work together to neutralize excess hydrogen ions (acid) or hydroxide ions (base), thereby stabilizing blood and cellular pH. Buffer systems are essential for normal cellular function because even minor deviations from normal blood pH (~7.35–7.45) can have severe physiological consequences[1][6]. However, "buffer anions" is not a specific molecular target for drug therapy; rather, it is a functional description of how certain molecules participate in maintaining acid-base equilibrium. In summary, this entry is incorrect as a therapeutic target because it refers to multiple chemical species and processes rather than any single defined molecule or druggable entity.

Other names

Buffer anionBuffer systemAcid-base bufferBlood buffer anionBicarbonate bufferPhosphate bufferProtein buffer