Target intelligence / Profile preview

Acid Ceramidase (ASAH1)

Target: ASAH1
Molecular classification: Enzyme, Hydrolase

Overview

Acid ceramidase (ASAH1) is a lysosomal enzyme that hydrolyzes ceramides into sphingosine and free fatty acids. It plays a crucial role in regulating cell differentiation, proliferation, apoptosis, and membrane composition. Deficiency leads to Farber disease. It is also implicated in cancer, Alzheimer’s, and diabetes, making it a therapeutic target.

Other names: N-acylsphingosine deacylase

Mechanism of action

Inhibition of acid ceramidase activity to increase ceramide levels or modulation of ceramide/sphingosine balance

Biological functions

Lipid metabolismCell differentiationCell proliferationApoptosisRegulation of ceramide and sphingosine levelsMyelin maintenance

Disease associations

Farber diseaseSpinal muscular atrophy with progressive myoclonic epilepsyCancerAlzheimer's diseaseType II diabetes

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