Acid phosphatase 4 (ACP4)

Acid phosphatase 4 (ACP4) is an integral membrane enzyme belonging to the histidine acid phosphatase family, with structural similarity to prostatic and lysosomal acid phosphatases[1][6]. It exhibits protein tyrosine phosphatase activity and binds receptor tyrosine kinases, notably ERBB4, where it may regulate their cleavage and signaling[2][4][7]. ACP4 is predominantly expressed in secretory-stage ameloblasts during tooth development, where it is essential for proper enamel formation—mutations in ACP4 cause hypoplastic amelogenesis imperfecta, characterized by thin and poorly mineralized enamel[1]. While its principal physiological role is in odontogenesis, ACP4's exact substrates, apart from possibly the ERBB4 receptor, remain insufficiently characterized in humans[2][7]. There are currently no known approved drugs selectively targeting ACP4, and its clinical significance is primarily in genetic and dental disorders rather than as a therapeutic target[1][2][6][7].

Other names

Testicular acid phosphataseACPTAI1JAcid phosphatase, testicular

For inhibitors of acid phosphatase enzymes in general: Inhibition of phosphate monoester hydrolysis\n- No specific approved drugs targeting ACP4 are reported in the search results or primary literature