Molecular Classification
Ion channel, Acid-sensing ion channel (ASIC), Degenerin/Epithelial Sodium Channel Superfamily
Other Names
ACCN2, BNaC2, Acid-sensitive cation channel 1
Disease Roles
NeurodegenerationStrokePain

Acid-sensing ion channel 1a Overview

Acid-sensing ion channel 1a (ASIC1a) is a proton-gated cation channel belonging to the Degenerin/Epithelial Sodium Channel (Deg/ENaC) superfamily. It forms homotrimeric or heterotrimeric channels that are activated by extracellular acidification, leading to Na+ and Ca2+ influx. ASIC1a is primarily expressed in the central and peripheral nervous systems and plays roles in synaptic plasticity, pain sensation, and neurodegeneration following stroke. Amiloride and other pharmacological inhibitors can block the channel.

Mechanism of Action

Proton-gated ion channel blocker

Biological Functions

Synaptic transmission
Learning
Memory formation
Fear conditioning
Nociception
Neuronal excitability control
Ion conduction

Disease Associations

Neurodegeneration
Stroke
Pain
Seizure
Epilepsy
Inflammatory axonopathy

Safety Considerations

  • Potential for off-target effects due to structural similarity with other ion channels.

Interacting Drugs

Amiloride