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Target intelligence / Profile preview
Acid-sensing ion channel 1a (ASIC1a)
- Target
- ASIC1a
- Molecular classification
- Ion channel, Acid-sensing ion channel (ASIC), Degenerin/Epithelial Sodium Channel Superfamily
01
Overview
Acid-sensing ion channel 1a (ASIC1a) is a proton-gated cation channel belonging to the Degenerin/Epithelial Sodium Channel (Deg/ENaC) superfamily. It forms homotrimeric or heterotrimeric channels that are activated by extracellular acidification, leading to Na+ and Ca2+ influx. ASIC1a is primarily expressed in the central and peripheral nervous systems and plays roles in synaptic plasticity, pain sensation, and neurodegeneration following stroke. Amiloride and other pharmacological inhibitors can block the channel.
- Other names
- ACCN2BNaC2Acid-sensitive cation channel 1
02
Mechanism of action
Proton-gated ion channel blocker
03
Biological functions
Synaptic transmissionLearningMemory formationFear conditioningNociceptionNeuronal excitability controlIon conduction
04
Disease associations
NeurodegenerationStrokePainSeizureEpilepsyInflammatory axonopathy
05
Safety considerations
Potential for off-target effects due to structural similarity with other ion channels.
06
Interacting drugs
Amiloride
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