Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A)

Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) is a small, highly conserved, primarily nuclear protein characterized by an N-terminal leucine-rich repeat (LRR) domain and a C-terminal acidic region. ANP32A is a multifunctional protein involved in regulation of chromatin modification and remodeling, transcriptional control (notably via inhibition of histone acetyltransferases as part of the INHAT complex), modulation of apoptosis (cell death), and inhibition of specific enzymes such as protein phosphatase 2A (PP2A) [1][2]. It acts as a regulatory node integrating signals that impact cell proliferation, differentiation, and death. ANP32A is implicated in several diseases, including cancer, inflammation, neurodegeneration, and is essential for the replication of certain influenza viruses in mammalian cells [3]. The precise physiological roles of ANP32A are context-dependent and can vary between tumor-suppressive and oncogenic, reflecting its diverse molecular interactions and regulatory capacity [1][2].

Other names

C15orf1LANPMAPMPHAP1PHAPIpp32I1PP2AmapmodulinHPPCnpotent heat-stable protein phosphatase 2A inhibitor I1PP2Aputative HLA-DR-associated protein Iputative human HLA class II associated protein Icerebellar leucine-rich acidic nuclear proteinepididymis secretory sperm binding proteinhepatopoietin Cninhibitor-1 of protein phosphatase-2Aleucine-rich acidic nuclear protein

Protein phosphatase 2A (PP2A) inhibition by direct interaction. Modulation of chromatin accessibility by blocking histone acetylation (acting within the INHAT complex). Facilitation or inhibition of transcription factor recruitment. Participation in replication complex assembly for influenza virus.