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Target intelligence / Profile preview
Acidic Mammalian Chitinase (AMCase)
- Target
- AMCase
- Molecular classification
- Enzyme, Glycosyl hydrolase family 18
01
Overview
Acidic mammalian chitinase (AMCase), also known as CHIA, is an enzyme belonging to the glycosyl hydrolase family 18 (GH18). It hydrolyzes chitin, a polymer of β-1,4-linked N-acetyl-D-glucosamine (GlcNAc), which is found in the exoskeletons of insects and crustaceans as well as fungal cell walls. AMCase functions optimally under acidic conditions and plays roles in both digestion and immune defense. Altered expression or function has been associated with several diseases, including asthma, chronic atrophic gastritis, and certain cancers.
- Other names
- CHIA
02
Biological functions
Chitin degradation (digestion)Innate immunity (anti-chitin invaders)Epithelial protection
03
Disease associations
AsthmaChronic atrophic gastritisOcular conjunctivitisType 2 diabetesPulmonary interstitial fibrosisTumors (e.g., gastric adenocarcinoma)Sepsis-induced kidney damage
04
Biomarkers
Chronic atrophic gastritisSepsis-induced kidney damage
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