Acidic nuclear phosphoprotein 32 family member B (ANP32B)

Acidic nuclear phosphoprotein 32 family member B (ANP32B) is a multifunctional, highly conserved nuclear protein characterized by N-terminal leucine-rich repeats and a low-complexity acidic region. It is involved in chromatin modification/remodeling, transcriptional regulation, histone chaperone activities, and cell cycle progression. ANP32B plays a distinct role in regulating apoptosis, acting as a negative regulator of caspase-3-dependent cell death and potentially antagonizing ANP32A activity in tissue homeostasis. It is essential for the nucleocytoplasmic transport of selective mRNAs via CRM1/XPO1 and is implicated in adequate adaptive immune responses. Disease relevance includes roles in cancer, viral infections (such as influenza), and possible links to neurodegenerative disorders and congenital myopathy. There is substantial functional overlap with other ANP32 family members, leading to compensatory biological mechanisms and variable necessity in development.

Other names

Acidic leucine-rich nuclear phosphoprotein 32 family member BAPRILPHAPI2SSP29Acidic protein rich in leucinesPutative HLA-DR-associated protein I-2Silver-stainable protein SSP29