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Target intelligence / Profile preview
Acinetobacter baumannii (A. baumannii)
- Target
- A. baumannii
- Molecular classification
- Bacterium, Gram-negative bacteria, Opportunistic pathogen
01
Overview
Acinetobacter baumannii is an opportunistic Gram-negative pathogen predominantly encountered as a cause of severe nosocomial infections due to its robust antibiotic resistance mechanisms—posing significant challenges for infection control worldwide. It is a strictly aerobic, non-motile, pleomorphic coccobacillus bacterium that primarily affects immunocompromised individuals, causing a range of infections including bloodstream infections, pneumonia, urinary tract infections, and wound infections. Its virulence factors include capsular polysaccharide, lipopolysaccharide, and biofilm formation. Treatment is challenging due to its extensive drug resistance.
- Other names
- AcinetobacterMultidrug-resistant Acinetobacter baumannii (MDRAB)
02
Mechanism of action
N/A
03
Biological functions
ColonizationInfectionBiofilm formationImmune evasion
04
Disease associations
PneumoniaBloodstream infections (sepsis)Urinary tract infectionsWound infectionsNosocomial infections
05
Safety considerations
Antibiotic resistanceMultidrug resistanceHigh mortality rate in immunocompromised individualsPersistence in hospital environments
06
Interacting drugs
Beta-lactam antibiotics
2 more in the full profile.
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