Aconitase 2 pseudogene 1 (ACO2P1)

ACO2 pseudogene 1 (ACO2P1) is a human pseudogene located on chromosome 22q13.31 (GRCh38/hg38: chr22:34589085-34591278). It exhibits sequence similarity to the functional Aconitase 2, mitochondrial (ACO2), an enzyme vital for mitochondrial energy metabolism in the TCA cycle. However, ACO2P1 is a non-coding genomic element classified as a pseudogene, meaning it lacks protein-coding capacity and does not produce a functional protein. Consequently, it has no confirmed biological or disease role, drug interaction, or utility as a therapeutic target. There is no evidence for therapeutic or biomarker relevance; it is not involved in disease mechanisms, drug interaction, or patient stratification. ACO2P1 is not considered a therapeutic target; it is a fossil genetic element derived from a once-functional gene that has lost its protein-coding function. Its clinical and functional significance remains unknown at this time. Standard sources (GeneCards, BioGPS) confirm ACO2P1 as a pseudogene without functional annotation[4][6].

Other names

ACO2P1ACO2 pseudogene 1