Acquired enamel pellicle (AEP)

The acquired enamel pellicle (AEP) is a thin, acellular, organic film that forms on the tooth surface within seconds after exposure to the oral environment through the selective adsorption of salivary proteins, glycoproteins, and lipids (Siqueira et al., 2012, J Dent Res). It serves as a critical interface between the tooth enamel and the oral environment, providing a protective barrier against acid-induced erosion and regulating the mineral balance of the tooth surface (Hannig & Joiner, 2006, Monogr Oral Sci). While the AEP is essential for lubrication and protection, it also acts as a scaffold for the initial attachment of oral bacteria, such as Streptococcus mutans, leading to the formation of dental plaque (Lendenmann et al., 2000, Adv Dent Res). Therapeutic strategies targeting the AEP often involve modifying its composition or permeability to enhance its acid-buffering capacity, deliver remineralizing agents like fluoride, or inhibit the adhesion of pathogenic microorganisms (Reynolds, 2008, J Dent Res). Understanding the molecular dynamics of the AEP, including the roles of statherin and mucins, is vital for developing advanced dental treatments for caries and periodontal diseases (Vila et al., 2015, Biofouling).

Other names

Salivary pellicleDental pellicleAcquired pellicleSalivary protein film

Modification of the pellicle's protective properties by enhancing acid resistance, inhibiting bacterial attachment through competitive binding or antimicrobial action, and promoting the deposition of remineralizing ions like calcium and phosphate (Reynolds, 2008, J Dent Res; Jones, 1997, Periodontol 2000).