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Acrosin-binding protein (ACRBP)
- Target
- ACRBP
- Molecular classification
- Other (cancer/testis antigen, acrosomal protein)
01
Overview
Acrosin-binding protein (ACRBP) is an acrosomal protein that maintains proacrosin as an enzymatically inactive zymogen in the sperm acrosome, playing a role in acrosome formation and function[2][5]. It is a member of the cancer/testis antigen family, being expressed in normal tissue almost exclusively in the testis but found aberrantly overexpressed in multiple tumor types (such as bladder, breast, lung, liver, and colon)[1][2]. ACRBP is immunogenic and serves as a potential biomarker and therapeutic target in cancers, as well as having a critical role in male fertility through its regulation of sperm acrosomal processes[1][2][5].
- Other names
- SP32CT23OY-TES-1Cancer/testis antigen 23Cancer/testis antigen OY-TES-1Proacrosin-binding protein sp32Testicular tissue protein Li 10
02
Biological functions
Acrosome formationMaintenance of proacrosin as inactive zymogenBinding and packaging acrosin in spermSperm functionImmunogenic (cancer/testis antigen)
03
Disease associations
CancerMale infertility (globozoospermia)Other (potential immune response in cancer)
04
Safety considerations
Potential off-target immune responseEssential for male fertility
05
Biomarkers
Cancer/testis antigen (biomarker for various cancers)Testis-specific expression in normal tissue
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