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Acrosin pseudogene 1 (ACRP1)
- Target
- ACRP1
- Molecular classification
- Other (Pseudogene)
01
Overview
Acrosin pseudogene 1 (ACRP1) is a human pseudogene related to the acrosin gene, which encodes a serine protease involved in sperm penetration of the zona pellucida[2]. ACRP1 itself represents a non-functional genomic sequence that may be transcribed but does not generate a functional protein. Pseudogenes like ACRP1 can sometimes influence cellular biology as competitive endogenous RNAs (ceRNAs), affecting regulation by sponging microRNAs, but there is no reported evidence that ACRP1 plays a significant regulatory or disease-related role[1][3]. It is not considered a molecular target for therapeutic intervention and is generally omitted from targetable gene/protein lists.
- Other names
- Acrosin pseudogene 1ACRP1acrosin pseudogeneACR pseudogene 1
02
Mechanism of action
Not applicable
03
Biological functions
May participate in competing endogenous RNA (ceRNA) regulatory functions if transcribed, such as sponging microRNAs that affect related genesOtherwise, no known direct protein or cellular functions, as it does not produce an active polypeptide
04
Disease associations
Pseudogenes in general can be involved in cancer and other diseases through RNA-mediated regulation, but there is no evidence for direct disease involvement of ACRP1 itselfIts parental gene (ACR, acrosin) is involved in diseases such as spermatogenic failure and varicocele, but ACRP1 has no established clinical relevance
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