ACTB pseudogene 11 (ACTBP11)

ACTB pseudogene 11 (ACTBP11) is a **processed pseudogene** that shares high sequence similarity with the functional ACTB (beta-actin) gene but is generally non-functional. Beta-actin pseudogenes are widely distributed across the human genome, and ACTBP11 is one of at least 64 ACTB-related pseudogenes. These pseudogenes are generally intronless, may be transcribed at low levels, but do not encode proteins and are not known to have biological roles. Their primary relevance in research relates to potential mispriming during RNA quantification techniques (RT-PCR), as pseudogene sequences can contaminate assays for ACTB expression, complicating data interpretation. ACTBP11 itself is not a drug target, biomarker, or associated with disease processes[4][5]. **Key considerations:** - Researchers should avoid using ACTB and its pseudogenes as reference genes in RT-PCR without confirming primer specificity, due to the abundance and similarity of pseudogene sequences[5]. - ACTBP11 is only relevant to genomics studies mapping the location and evolution of pseudogenes in the genome, rather than to molecular pharmacology or disease biology. **Summary:** ACTBP11 is a *pseudogene*, not a functional protein or therapeutic target, and has no known biological, pathological, or pharmacological relevance[4][5].

Other names

Beta-actin pseudogene 11ACTB PG11ACTBP11

None. No drug mechanism is relevant for ACTBP11.