Actin-associated LIM protein (ALP)

Actin-associated LIM protein (ALP), encoded by the *PDLIM3* gene, is a cytoskeletal adaptor that contains both a PDZ domain and a LIM domain, allowing it to anchor and organize actin filaments within muscle cells[1][2][4]. ALP is highly expressed in heart and skeletal muscle, where it localizes primarily to Z-discs and intercalated discs, playing a crucial role in myofibrilogenesis and muscle fiber contractility[1]. It supports cross-linking of actin filaments by α-actinin-2 and is essential for correct cardiac chamber formation and function, as highlighted in knockout mouse models where its absence causes right ventricular malformations and cardiomyopathy. Structural studies show that ALP and other PDLIM family proteins function mainly as scaffolds linking cytoskeletal and membrane-associated proteins, thereby influencing subcellular localization and actin filament organization[2]. No direct drug-targeting or biomarker utility has been established for PDLIM3/ALP to date.

Other names

PDZ and LIM domain protein 3PDLIM3ALP