Actin beta-like protein 2 (ACTBL2)

Actin beta-like protein 2 (ACTBL2) is a non-muscle actin isoform, structurally similar to beta-actin but genetically distinct, with the highest number of non-conserved amino acid substitutions among human actins[1][7]. It is involved in the regulation of the cytoskeleton, modulating processes such as cell motility, migration, proliferation, and focal adhesion formation[1][3][4]. ACTBL2 directly interacts with actin-binding proteins like gelsolin and is a component of lamellipodia, filopodia, and stress fibers, structures critical for dynamic cell movement and invasion[1][4]. Its expression is upregulated in several cancers and correlates with poor prognosis, especially in ovarian, colorectal, pancreatic, and hepatocellular carcinomas, making it a promising biomarker and potential therapeutic target for cancer diagnostics and progression monitoring[3][4][7]. There are currently no drugs specifically targeting ACTBL2, but its central role in actin dynamics underscores its biological significance in disease contexts.

Other names

Beta-actin-like protein 2DKFZp686D0972Kappa-actinACTActin-like protein

Not directly applicable; as a structural protein, most molecular interventions would likely modulate actin dynamics or impact cell migration and invasion