Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Actin-binding LIM protein 3 (ABLIM3)
- Target
- ABLIM3
- Molecular classification
- Cytoskeletal protein, Scaffold protein, LIM domain protein, Microfilament protein, Other
01
Overview
Actin-binding LIM protein 3 (ABLIM3) is a cytoskeletal scaffold protein encoded by the ABLIM3 gene in humans and other vertebrates. It contains four LIM domains (which facilitate protein-protein interactions) and a dematin-like domain involved in actin filament binding. ABLIM3 contributes to cellular adhesion, migration, and polarity, operating as a molecular linker between actin filaments and signaling pathways. It is highly expressed in heart, lung, liver, and the nervous system. ABLIM3 is implicated in disease mechanisms including cancer progression, neurodevelopmental disorders, asthma, and cardiovascular disease, but is not recognized as a direct therapeutic target. Related proteins and paralogs include ABLIM1 and LIMS1.
- Other names
- ABLIM3Actin binding LIM protein family member 3abLIM3KIAA0843HMFN1661
02
Mechanism of action
Not applicable—no drugs reported targeting ABLIM3.
03
Biological functions
Cell adhesionCell migrationCell polarityEmbryonic developmentRegulation of actin cytoskeletonSignal transduction (linking actin dynamics to transcriptional control)
04
Disease associations
Cancer (tumor growth, metastasis)Asthma (involved in airway inflammation and hyperresponsiveness)Cardiovascular disease (vascular development and homeostasis)Neurological disorders (synaptic function, neuronal development, neurodevelopmental disorders)Joubert Syndrome 17Hepatoblastoma
Beyond the preview
Go deeper on Actin-binding LIM protein 3 (ABLIM3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Actin-binding LIM protein 3 (ABLIM3).