Actin filament-associated protein 1 (AFAP1)

Actin filament-associated protein 1 (AFAP1) is an adaptor and scaffold protein that interacts with actin filaments and links them to key signaling molecules, notably the SRC family kinases and protein kinase C. AFAP1 modulates cytoskeletal integrity and dynamics in response to cellular signals, promoting the assembly of structures crucial for cell adhesion, migration, and invasion such as podosomes and focal adhesions[1][2][3]. It plays an important regulatory role in cancer cell motility and has been implicated in tumor progression and metastasis[2][3]. Additionally, the AFAP1 gene locus encodes an antisense long non-coding RNA (AFAP1-AS1) that acts as an oncogenic regulator in various tumors[1][4]. AFAP1 is mainly classified as a cytoskeletal adaptor protein rather than a classic enzyme, transporter, or receptor, but its involvement in signal transduction and cancer biology makes it a potential therapeutic target.

Other names

AFAP-110AFAPAFAP110110 kDa actin filament-associated proteinActin filament-associated protein, 110 kDa

No direct small molecule inhibitors reported; the protein acts chiefly as a scaffold/adaptor influencing downstream signaling such as SRC and protein kinase C pathways[1][2][3].