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Target intelligence / Profile preview
Actin filament-associated protein 1-like 1 (AFAP1L1)
- Target
- AFAP1L1
- Molecular classification
- Other (Adaptor/Scaffold protein), Actin cytoskeleton-associated protein
01
Overview
Actin filament-associated protein 1-like 1 (AFAP1L1) is a member of the AFAP family, which includes AFAP1 and AFAP1L2/XB130[2][3][1][8]. AFAP1L1 is a cytoskeletal adaptor protein that localizes to actin filaments and invadosomes, interacts preferentially with cortactin, and is essential for actin remodeling in cell migration, invasion, and morphology regulation[1][3]. It is upregulated in certain malignancies, making it a predictive biomarker for metastasis and a putative therapeutic target, particularly in colorectal cancers and spindle cell sarcoma[3][7][8]. Recent studies highlight AFAP1L1’s role as a hypoxia-related regulatory protein, activated by HIF-1α and essential for pathological angiogenesis via the YAP-DLL4-NOTCH axis in endothelial tip cell dynamics[2]. AFAP1L1’s function is distinct but overlapping with other AFAP family members and is involved in regulating tumor cell proliferation, migration, invasion, and EMT[2][3][7][8].
- Other names
- AFAP1L1AFAP1-like protein 1FLJ36748actin filament-associated protein 1-like 1
02
Mechanism of action
No direct drugs; inhibition of AFAP1L1 disrupts endothelial tip cell behavior via the YAP-DLL4-NOTCH axis, halting neovascularization
03
Biological functions
Actin cytoskeletal remodelingCell migrationCell invasionCell morphology regulationAngiogenesis regulationEpithelial-mesenchymal transition (EMT)
04
Disease associations
Cancer (promotes cell invasion, predicts metastasis, implicated in colorectal cancer and spindle cell sarcoma)Pathological angiogenesis (tumor and ocular neovascularization)Congenital disorder association (Coffin-Siris Syndrome 8)
05
Safety considerations
Not established (targeted suppression impairs angiogenesis; full toxicity profile is unknown)
06
Biomarkers
AFAP1L1 gene/protein expression level (marker for metastasis in colorectal and spindle cell sarcomas)
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